反应详情

To a refluxing solution of 11.1 g (0.04 mol) of 2-[1-hydroxy-6'-(1-hydroxypentyl)-benzyl]pyridine in 250 mL of benzene was added 23.9 mL (0.14 mol) of triflic anhydride in 5 min, the mixture was heated for 65 min and then cooled. The reaction mixture was concentrated in vacuo, the residual oil was triturated in ether and decanted. The oil was chromatographed on silica (ethyl acetate/methylene chloride, 1:1 ) to afford an oil, which was treated with sodium perchlorate solution. The salt was triturated in hot water, decanted, and the residue crystallized on cooling. The above solid was crystallized (2×) from ethyl acetate/methylene chloride to afford 1.5 g (11%) of 6-butylbenzo[b]quinolizinium perchlorate (Formula II: R1 =R7 =H; R2 =n-butyl; X- =ClO4-), as a pale solid, m.p. 174°-177° C.

1. temperaturethe mixture was heated for 65 min
2. temperaturecooled
3. concentrationThe reaction mixture was concentrated in vacuo
4. customthe residual oil was triturated in ether
5. customdecanted
6. customThe oil was chromatographed on silica (ethyl acetate/methylene chloride, 1:1 )
7. customto afford an oil, which
8. customThe salt was triturated in hot water
9. customdecanted
10. customthe residue crystallized
11. temperatureon cooling
12. customThe above solid was crystallized (2×) from ethyl acetate/methylene chloride