反应详情

A solution of 0.10 g (0.51 mmol) of 4-cyano-4'-hydroxybiphenyl and 0.10 g (0.72 mmol) of potassium carbonate dissolved in 4 ml of 2-butanone was refluxed. After addition of 0.10 g (0.55 mmol) of 6-bromohexan-1-ol to the reaction mixture, the whole was refluxed overnight. After removal of the solvent by distillation, water was added to the residue and the whole was extracted with methylene chloride. The extract was purified by silica gel column chromatography. The resulting white solid was recrystallized from hexane to obtain 0.10 g of 4-cyano-4'(6-hydroxyhexyloxy)biphenyl (9) (yield: 66.4%).

1. temperaturewas refluxed
2. temperaturethe whole was refluxed overnight
3. customAfter removal of the solvent
4. distillationby distillation, water
5. additionwas added to the residue
6. extractionthe whole was extracted with methylene chloride
7. customThe extract was purified by silica gel column chromatography
8. customThe resulting white solid was recrystallized from hexane