Hydrochloric Acid → N-(3-isopropoxyphenylacetyl)-N-(2-methoxyethyl)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine

HRID 742637Notes

Reaction equation

HRID 742637 reaction equation
Cl.[CH:2]([O:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([N:15]([CH2:20][CH:21]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[C:33]([Cl:38])[CH:32]=2)[CH2:22][CH2:23][O:24]C2CCCCO2)[CH2:16][CH2:17][O:18][CH3:19])=[O:14])[CH:9]=[CH:10][CH:11]=1)([CH3:4])[CH3:3]>C(OCC)C.CO>[CH:2]([O:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([N:15]([CH2:20][CH:21]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[C:33]([Cl:38])[CH:32]=2)[CH2:22][CH2:23][OH:24])[CH2:16][CH2:17][O:18][CH3:19])=[O:14])[CH:9]=[CH:10][CH:11]=1)([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19705328N-(3-isopropoxyphenylacetyl)-N-(2-methoxyethyl)-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamine

Product 1

HCID 19705329N-(3-isopropoxyphenylacetyl)-N-(2-methoxyethyl)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

A saturated solution of hydrochloric acid in diethylether is added to a solution of 2.2 g of the product obtained in step 3 in 30 ml of methanol, until the obtention of a pH value of 1.

Sources & evidence

ORD record
ord-02c432f286534a3280cac4f0f398a550
Source dataset
uspto-grants-1996_09
Patent number
US05554763

Reaction notes

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