反应详情

温度

80 °C

2 g of the product prepared in step 5 and 1 g of 4-phenylquinuclidine are dissolved in 2 ml of dimethylformamide and the reaction mixture is heated at 80° C. for 4 hours. After cooling, the reaction mixture is poured into water and then successively extracted with ethyl acetate, washed with a 5% solution of hydrochloric acid, with a saturated solution of NaCl, dried over Na2SO4 and concentrated under vacuum.

1. temperatureAfter cooling
2. extractionsuccessively extracted with ethyl acetate
3. washwashed with a 5% solution of hydrochloric acid, with a saturated solution of NaCl
4. dry with materialdried over Na2SO4
5. concentrationconcentrated under vacuum