反应详情

To a methanol (5 mL) solution of 2-(2-(3,3,3-trifluoropropyl)aminoanilin-5-yl)benzoxazole (see Working Example 85-1) (300 mg, 0.93 mmol) was added methyl acetimidate hydrochloride (120 mg, 1.11 mmol), and this was heated to reflux for 3 hours. After the reaction was complete, saturated aqueous sodium hydrogen carbonate solution was added, and this was extracted with chloroform. The organic layer obtained was dried over anhydrous sodium sulfate, after which it was filtered and concentrated to yield the title compound (250 mg, 93% yield) as white crystals.

1. temperaturethis was heated
2. temperatureto reflux for 3 hours
3. extractionthis was extracted with chloroform
4. customThe organic layer obtained
5. dry with materialwas dried over anhydrous sodium sulfate
6. filtrationafter which it was filtered
7. concentrationconcentrated