反应详情

To a solution of 5-(5-aminobenzoxazol-2-yl)-2-methyl-1-n-propylbenzimidazole (see Working Example 82-4) (200 mg, 0.653 mmol) in chloroform (5 mL) was added triethylamine (132 mg, 1.31 mmol) and acetic anhydride (100 mg, 0.979 mmol), and this was stirred at room temperature for 20 hours. After the reaction was complete, the solution was concentrated, the precipitated crystals were filtered, and after washing with water were dried to yield the title compound (176 mg, 77% yield) as pale yellow crystals.

1. concentrationthe solution was concentrated
2. filtrationthe precipitated crystals were filtered
3. washafter washing with water
4. customwere dried