反应详情

To 1 gm of valine benzyl ester p-toluene-sulfonic acid salt in 40 ml of CH2Cl2 at 0° C. was added 1.12 gm of 4 -pyridylsulfonyl chloride (U. S. Pat. #431504 (1982)) and 1.9 ml of triethylamine. After 1 hour, the solution was washed. with water and extracted with CH2Cl2 (2×100 ml), dried and concentrated. Silica gel column chromotography provided 4-pyridyl-ethanesulfonyl-valine benzyl ester which was treated with 10% Pd/C in methanol under hydrogen atmosphere to provide the desired product in 85% overall yeild.

1. washthe solution was washed
2. extractionwith water and extracted with CH2Cl2 (2×100 ml)
3. customdried
4. concentrationconcentrated