反应详情

2-[(6-Aminohexoxyhydroxyphosphinyl)oxy-N,N,N-trimethylethanaminium hydroxide, inner salt (90 mg, 0.28 mmol) was dissolved in dry dimethyl sulphoxide (2 ml). Triethylamine (197 μl, 1.41 mmol) was added, followed by N-succinimidyl 3-(2-pyridyldithio)propionate (88 mg, 0.28 mmol). The mixture was stirred at ambient temperature for eighteen hours. The solvent was evaporated under vacuum at a temperature of 60° C. and re-evaporated from methanol. The residue was chromatographed on silica gel eluting with methanol. The relevant fractions were combined and evaporated to dryness to give 2[N(3-(2 pyridyldithio)propionyl)(6-aminohexoxyhydroxy

1. customThe solvent was evaporated under vacuum at a temperature of 60° C.
2. customre-evaporated from methanol
3. customThe residue was chromatographed on silica gel eluting with methanol
4. customevaporated to dryness
5. customto give 2[N(3-(2 pyridyldithio)propionyl)(6-aminohexoxyhydroxy