反应详情

To 2-(4-chloro-2-(tetrahydropyran-4-yl)aminonitrobenzen-5-yl)benzoxazole (see Working Example 112-2) (0.10 g, 0.8 mmol) was added iron powder (0.33 g, 5.8 mmol) and acetic acid (50 mL), and this was heated to reflux for 2 hours. After the reaction solution cooled, this was filtered through Celite and concentrated, and the residue obtained was purified by silica gel column chromatography to yield the title compound (0.06 g, 65% yield) as a reddish-brown solid.

1. temperaturethis was heated
2. temperatureto reflux for 2 hours
3. temperatureAfter the reaction solution cooled
4. filtrationthis was filtered through Celite
5. concentrationconcentrated
6. customthe residue obtained
7. customwas purified by silica gel column chromatography