Dichloromethane → 6-Benzyl-3-methyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dionehydrochloride

HRID 742962Notes

Reaction equation

HRID 742962 reaction equation
[CH2:1]([N:8]1[CH2:20][CH2:19][C:11]2[NH:12][C:13](=[O:18])[N:14]([CH3:17])[C:15](=[O:16])[C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:21]CCl>>[ClH:21].[CH2:1]([N:8]1[CH2:20][CH2:19][C:11]2[NH:12][C:13](=[O:18])[N:14]([CH3:17])[C:15](=[O:16])[C:10]=2[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 100160286-benzyl-3-methyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione

Product 1

HCID 194233536-Benzyl-3-methyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dionehydrochloride

Procedure

14.3 g of 6-benzyl-3-methyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione were dissolved in 300 ml of dichloromethane, and 6-benzyl-3-methyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione hydrochloride was precipitated with a solution of hydrochloric acid in ether, while cooling with ice. The product was purified by recrystallization from isopropanol.

Workup

  1. custom6-benzyl-3-methyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione hydrochloride was precipitated with a solution of hydrochloric acid in ether
  2. temperaturewhile cooling with ice
  3. customThe product was purified by recrystallization from isopropanol

Sources & evidence

ORD record
ord-b878da169a814773b29343362eec12fe
Source dataset
uspto-grants-1996_09
Patent number
US05556854

Reaction notes

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