HCID 19423555, compound → HCID 19423571, compound

HRID 743069Notes

Reaction equation

HRID 743069 reaction equation
C([O:3][C:4]([CH2:6][N:7]1[CH2:12][CH2:11][CH:10]([N:13]2[CH:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:15][C:14]2=[O:29])[CH2:9][CH2:8]1)=O)C.[NH3:30].CO>>[C:4]([CH2:6][N:7]1[CH2:8][CH2:9][CH:10]([N:13]2[CH:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:15][C:14]2=[O:29])[CH2:11][CH2:12]1)(=[O:3])[NH2:30]

Participants

3

Reactant 2

HCID 19423555HCID 19423555, compoundHCID 21705897Ammonia methanol

Product 1

HCID 19423571HCID 19423571, compound

Procedure

A solution of 200 mg (0.508 mmol) of 3-(1-ethoxycarbonylmethylpiperidin-4-yl)-4-phenyl-3,4-dihydro -2(1H)-quinazolinone in ammonia/methanol (6.09M, 30 mL) was stirred in an autoclave for 6 hours at temperature of approximately 150° C. After being cooled, the reaction mixture was concentrated in vacuo, and the residue was purified by means of column chromatography (silica gel, 1:9 methanol:chloroform) to give 167 mg (0.45 mmol) of the title compound.

Workup

  1. temperatureAfter being cooled
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. customthe residue was purified by means of column chromatography (silica gel, 1:9 methanol:chloroform)

Sources & evidence

ORD record
ord-b2c6af28a0b4417eafdd38596e2bb8ec
Source dataset
uspto-grants-1996_09
Patent number
US05556860

Reaction notes

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