HCID 19423555, compound → HCID 19423571, compound

Participants

Reaction Steps

A solution of 200 mg (0.508 mmol) of 3-(1-ethoxycarbonylmethylpiperidin-4-yl)-4-phenyl-3,4-dihydro -2(1H)-quinazolinone in ammonia/methanol (6.09M, 30 mL) was stirred in an autoclave for 6 hours at temperature of approximately 150° C. After being cooled, the reaction mixture was concentrated in vacuo, and the residue was purified by means of column chromatography (silica gel, 1:9 methanol:chloroform) to give 167 mg (0.45 mmol) of the title compound.

Provenance & Evidence