Hydrochloric Acid → 2-(2-Methylthioethoxy)aniline

HRID 743134ノート

反応式

HRID 743134 の反応式
O.O.[Sn](Cl)(Cl)(Cl)Cl.[CH3:8][S:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-])=O.Cl.[OH-].[Na+]>C(O)C>[CH3:8][S:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH2:19]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 539101632-(2-Methylthioethoxy)nitrobenzeneHCID 85782573Tin tetrachloride dihydrate

生成物 1

HCID 542131632-(2-Methylthioethoxy)aniline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Tin chloride dihydrate (57.9 g, 0.26 mole) in ethyl alcohol (90 ml) was added to a mixture of 2-(2-methylthioethoxy)nitrobenzene (18.1 g, 0.085 mole), conc. HCl (72.4 ml) and ethyl alcohol (36 ml). The reaction mixture was stirred for 24 h at room temperature. Sodium hydroxide (6M, 270 ml) was added to the reaction mixture. Extraction with methylene chloride (3×400 ml) gave after drying the organic layer over sodium sulfate and evaporation of the solvent 14.8 g (95%) of the title compound.

後処理

  1. extractionExtraction with methylene chloride (3×400 ml)
  2. customgave
  3. customafter drying the organic layer
  4. customover sodium sulfate and evaporation of the solvent 14.8 g (95%) of the title compound

出典と根拠

ORDレコード
ord-62ec2cb96514463785aa06dbf2c45bc6
出典データセット
uspto-grants-1996_09
特許番号
US05556863

反応ノート

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