Sodium hydride → N,N-Dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine

Beteiligte Stoffe

Reaktionsschritte

Following a procedure similar to that described in Example 2, 226 mg of 2-(4-phenylbutyl)phenol (prepared as described in Preparation 3), 96 mg of sodium hydride (as a 55% w/w dispersion in mineral oil) and 173 mg of dimethylaminoethyl chloride hydrochloride were reacted in dimethylacetamide. The crude product extracted was purified by column chromatography through silica gel, using a 20:1 by volume mixture of methylene chloride and methanol as the eluent, to give 230 mg (yield 77%) of the title compound as an oil.

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