反应详情

Following a procedure similar to that described in Example 2, 226 mg of 2-(4-phenylbutyl)phenol (prepared as described in Preparation 3), 96 mg of sodium hydride (as a 55% w/w dispersion in mineral oil) and 173 mg of dimethylaminoethyl chloride hydrochloride were reacted in dimethylacetamide. The crude product extracted was purified by column chromatography through silica gel, using a 20:1 by volume mixture of methylene chloride and methanol as the eluent, to give 230 mg (yield 77%) of the title compound as an oil.

1. extractionThe crude product extracted
2. customwas purified by column chromatography through silica gel
3. additionby volume mixture of methylene chloride and methanol as the eluent