1-Chloro-2-(diethylamine)ethane hydrochloride → N,N-Diethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine

참여 물질

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Following a procedure similar to that described in Example 2, 340 mg of 2-(4-phenylbutyl)phenol (prepared as described in Preparation 3), 140 mg of sodium hydride (as a 55% w/w dispersion in mineral oil) and 310 mg of 2-diethylaminoethyl chloride hydrochloride were reacted in 20 ml of dimethylacetamide. The crude product, extracted following the procedure of Example 2, was purified by column chromatography through silica gel, using a 30:1 by volume mixture of methylene chloride and methanol as the eluent, to give 480 mg (yield 98%) of the title compound as an oil.

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