反应详情

Following a procedure similar to that described in Example 2, 340 mg of 2-(4-phenylbutyl)phenol (prepared as described in Preparation 3), 140 mg of sodium hydride (as a 55% w/w dispersion in mineral oil) and 310 mg of 2-diethylaminoethyl chloride hydrochloride were reacted in 20 ml of dimethylacetamide. The crude product, extracted following the procedure of Example 2, was purified by column chromatography through silica gel, using a 30:1 by volume mixture of methylene chloride and methanol as the eluent, to give 480 mg (yield 98%) of the title compound as an oil.

1. extractionThe crude product, extracted
2. customwas purified by column chromatography through silica gel
3. additionby volume mixture of methylene chloride and methanol as the eluent