反应详情

Following a procedure similar to that described in Example 2, 340 mg of 2-(4-phenylbutyl)phenol (prepared as described in Preparation 3), 330 mg of 4-(2-chloroethyl)morpholine hydrochloride and 140 mg of sodium hydride (as a 55% w/w dispersion in mineral oil) were reacted in 20 ml of dimethylacetamide. The crude product, extracted as described in Example 2, was purified by column chromatography through silica gel, using a 3:2 by volume mixture of ethyl acetate and hexane as the eluent, to give 390 mg (yield 76%) of the title compound as a colorless oil.

1. extractionThe crude product, extracted
2. customwas purified by column chromatography through silica gel
3. additionby volume mixture of ethyl acetate and hexane as the eluent