反应详情

2 ml of 50% by volume aqueous dimethylamine were added to a solution of 319 mg of 2-{2-[4-(2-cyanophenyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] in 10 ml of tetrahydrofuran, and the resulting mixture was reacted and worked-up in a similar manner to that described in Example 1(b). The resulting crude product was then purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 267 mg (yield 73%) of the title compound as a colorless oil.

1. customthe resulting mixture was reacted and worked-up in a similar manner to that
2. customThe resulting crude product was then purified by column chromatography through silica gel
3. additionby volume mixture of methylene chloride and methanol as the eluent