Dimethylamine → 1-{2-[4-(3,5-Dimethoxyphenyl)butyl]phenoxy}-3-dimethylamino-2-propanol

HRID 743190Notes

Reaction equation

HRID 743190 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=2[O:17][CH2:18][CH:19]2[CH2:21][O:20]2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[CH3:26][NH:27][CH3:28]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=2[O:17][CH2:18][CH:19]([OH:20])[CH2:21][N:27]([CH3:28])[CH3:26])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 108311692-{2-[4-(3,5-Dimethoxyphenyl)butyl]phenoxymethyl}oxirane

Product 1

HCID 106222221-{2-[4-(3,5-Dimethoxyphenyl)butyl]phenoxy}-3-dimethylamino-2-propanolYield 62%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 1(b), a solution of 0.42 g of 2-{2-[4-(3,5-dimethoxyphenyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] in 10 ml of tetrahydrofuran was treated with 2 ml of 50% by volume aqueous dimethylamine. After purification, 0.29 g (yield 62%) of the title compound was obtained as a colorless oil.

Workup

  1. customAfter purification

Sources & evidence

ORD record
ord-a3805a8e66004622a4841bf111550d17
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

Loading…