Dimethylamine → HCID 19423868, compound

HRID 743200Notes

Reaction equation

HRID 743200 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:24]=[CH:23][CH:22]=[CH:21][C:15]=2[O:16][CH2:17][CH:18]2[CH2:20][O:19]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH3:25][NH:26][CH3:27]>O1CCCC1>[CH3:25][N:26]([CH3:27])[CH2:20][CH:18]([OH:19])[CH2:17][O:16][C:15]1[CH:21]=[CH:22][CH:23]=[CH:24][C:14]=1[CH2:13][CH2:12][CH2:11][CH2:10][C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19423887HCID 19423887, compound

Product 1

HCID 19423868HCID 19423868, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 1(b), a solution of 648 mg of 2-{2-[4-(4-isopropylphenyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] in 13 ml of tetrahydrofuran was treated with 2.6 ml of 50% by volume aqueous dimethylamine. The reaction mixture was worked up and purified as described in Example 1(b), to give 703 mg (yield 95%) the title compound as a colorless oil.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-346ae7c6acc24811aaedb259d774ae4e
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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