Hydrochloric Acid → 3-(Imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol hydrochloride

Participants

Reaction Steps

1.7 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 790 mg of 3-(imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol [prepared as described in step (a) above] in ethyl acetate, and the resulting mixture was allowed to stand at room temperature for 3 hours. The crystals which precipitated were collected by filtration and dried in vacuo, to give 810 mg (yield 92%) of the title compound as colorless crystals, melting at 128°-130° C.

Provenance & Evidence