Hydrochloric Acid → 3-(Imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol hydrochloride

HRID 743207Notes

Reaction equation

HRID 743207 reaction equation
[ClH:1].[N:2]1([CH2:7][CH:8]([OH:27])[CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=[CH:5][N:4]=[CH:3]1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[N:2]1([CH2:7][CH:8]([OH:27])[CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 194239523-(Imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol

Product 1

HCID 194239513-(Imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol hydrochlorideYield 92%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

1.7 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 790 mg of 3-(imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol [prepared as described in step (a) above] in ethyl acetate, and the resulting mixture was allowed to stand at room temperature for 3 hours. The crystals which precipitated were collected by filtration and dried in vacuo, to give 810 mg (yield 92%) of the title compound as colorless crystals, melting at 128°-130° C.

Workup

  1. customThe crystals which precipitated
  2. filtrationwere collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-abf38b009ada4d9a92c86e765741910d
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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