Dimethylamine → HCID 19423938, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 1(b), a solution of 0.63 g of 2-{2-[4-(4-methylphenyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] in 10 ml of tetrahydrofuran was treated with 2 ml of 50% by volume aqueous dimethylamine. The crude product thus obtained was purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 0.65 g (yield 89%) of the title compound as a colorless oil.

Provenance & Evidence