Dimethylamine → HCID 19423938, compound

HRID 743211Notes

Reaction equation

HRID 743211 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:22]=[CH:21][CH:20]=[CH:19][C:13]=2[O:14][CH2:15][CH:16]2[CH2:18][O:17]2)=[CH:4][CH:3]=1.[CH3:23][NH:24][CH3:25]>O1CCCC1>[CH3:23][N:24]([CH3:25])[CH2:18][CH:16]([OH:17])[CH2:15][O:14][C:13]1[CH:19]=[CH:20][CH:21]=[CH:22][C:12]=1[CH2:11][CH2:10][CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19423936HCID 19423936, compound

Product 1

HCID 19423938HCID 19423938, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 1(b), a solution of 0.63 g of 2-{2-[4-(4-methylphenyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] in 10 ml of tetrahydrofuran was treated with 2 ml of 50% by volume aqueous dimethylamine. The crude product thus obtained was purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 0.65 g (yield 89%) of the title compound as a colorless oil.

Workup

  1. customThe crude product thus obtained
  2. customwas purified by column chromatography through silica gel
  3. additionby volume mixture of methylene chloride and methanol as the eluent

Sources & evidence

ORD record
ord-4d8cd4cf9d4d45bab9f09502deb0a754
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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