Hydrochloric Acid → 1-{2-[4-(2-Chlorophenyl)butyl]phenoxy}-3-dimethylamino-2-propanol hydrochloride

HRID 743221Notes

Reaction equation

HRID 743221 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=1[O:14][CH2:15][CH:16]([OH:21])[CH2:17][N:18]([CH3:20])[CH3:19].Cl>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=1[O:14][CH2:15][CH:16]([OH:21])[CH2:17][N:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 194239181-{2-[4-(2-Chlorophenyl)butyl]phenoxy}-3-dimethylamino-2-propanol

Product 1

HCID 194240221-{2-[4-(2-Chlorophenyl)butyl]phenoxy}-3-dimethylamino-2-propanol hydrochlorideYield 144.6%

Procedure

Following a procedure similar to that described in Example 17(c), 500 mg of 1-{2-[4-(2-chlorophenyl)butyl]phenoxy}-3-dimethylamino-2-propanol [prepared as described in step (b) above] were converted to the hydrochloride by passing it through a column packed with CM Sephadex C-25 (H+ type). The crude product was purified as described in Example 17(c), to give 398 mg (yield 72%) of the title compound as a colorless oil.

Workup

  1. customThe crude product was purified

Sources & evidence

ORD record
ord-808c8ed7059d43d2b92789f369698b74
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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