Dimethylamine → HCID 19423905, compound

HRID 743232Notes

Reaction equation

HRID 743232 reaction equation
[C:1]1([CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=2[O:17][CH2:18][CH:19]2[CH2:21][O:20]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH3:26][NH:27][CH3:28]>O1CCCC1>[CH3:26][N:27]([CH3:28])[CH2:21][CH:19]([OH:20])[CH2:18][O:17][C:16]1[CH:22]=[CH:23][CH:24]=[CH:25][C:15]=1[CH2:14][CH2:13][CH2:12][CH2:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19424029HCID 19424029, compound

Product 1

HCID 19423905HCID 19423905, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 1(b), 300 mg of 2-{2-[4-(1-naphthyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] dissolved in 6 ml of tetrahydrofuran were treated with 1.2 ml of 50% by volume aqueous dimethylamine. The crude product was purified as described in Example 1(b), to give 265 mg (yield 77%) of the title compound as a colorless oil.

Workup

  1. customThe crude product was purified

Sources & evidence

ORD record
ord-1d2a33ec966946fdb34bba48fafef7c8
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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