Hydrochloric Acid → HCID 19424016, compound

HRID 743233Notes

Reaction equation

[CH3:1][N:2]([CH3:28])[CH2:3][CH:4]([OH:27])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1.[ClH:29]>>[ClH:29].[CH3:28][N:2]([CH3:1])[CH2:3][CH:4]([OH:27])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19423905HCID 19423905, compound

Product 1

HCID 19424016HCID 19424016, compoundYield 60%

Procedure

Following a procedure similar to that described in Example 17(c), 265 mg of 3-dimethylamino-1-{2-[4-(1-naphthyl) butyl]phenoxy}-2-propanol [prepared as described in step (b) above] were converted the hydrochloride by passing it through a column packed with CM Sephadex C-25 (H+ type), to give 200 mg (yield 60%) of the title compound as a colorless oil.

Sources & evidence

ORD record: ord-512bfa0d278f4365b5cfe9474d903da4
Source dataset: uspto-grants-1996_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05556864

Reaction notes

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