Epibromohydrin → HCID 19424021, compound

HRID 743234Notes

Reaction equation

HRID 743234 reaction equation
[CH3:1][CH:2]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11].[CH3:19][C:20](C)([O-:22])[CH3:21].[K+].C(C1OC1)Br>CC(N(C)C)=O>[CH3:1][CH:2]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:19][CH:20]1[CH2:21][O:22]1

Participants

5

Reactant 3

HCID 18430EpibromohydrinHCID 19424024HCID 19424024, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 19424021HCID 19424021, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Following a procedure similar to that described in Example 1(a), 0.98 g of 2-(3-methyl-4-phenylbutyl)phenol (prepared as described in Preparation 13), 0.46 of potassium t-butoxide and 0.56 g of epibromohydrin were reacted in 10 ml of dimethylacetamide. The crude product, extracted as described in Example 1(a), was purified as described in Example 1(a), to give 1.0 g (yield 83%) of the title compound as a colorless oil.

Workup

  1. extractionThe crude product, extracted
  2. customwas purified

Sources & evidence

ORD record
ord-35ed4d5e6d7541339622eda89ce4e160
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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