Hydrochloric Acid → 2-{2-[2-(4-Phenylbutyl)phenoxy]ethyl}piperidine hydrochloride

HRID 743238Notes

Reaction equation

HRID 743238 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH2:24][CH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[C:28]1([CH2:27][CH2:26][CH2:25][CH2:24][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH2:16][CH2:15][CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][NH:9]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 108367361-t-Butoxycarbonyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine

Product 1

HCID 194239802-{2-[2-(4-Phenylbutyl)phenoxy]ethyl}piperidine hydrochlorideYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

10 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 1.13 g of 1-t-butoxycarbonyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine [prepared as described in step (b) above] in 10 ml of dioxane, and the resulting mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure. The resulting residue was washed with hexane and dried in vacuo, to give 0.94 g (yield 97%) of the title compound as a colorless oil.

Workup

  1. distillationAt the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure
  2. washThe resulting residue was washed with hexane
  3. customdried in vacuo

Sources & evidence

ORD record
ord-895a9fea50b34cfea0b7205a25fe6ae1
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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