Hydrochloric Acid → HCID 19424037, compound

HRID 743256Notes

Reaction equation

HRID 743256 reaction equation
COC[O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][C:13]2[CH:26]=[CH:25][CH:24]=[CH:23][C:14]=2[O:15][CH2:16][CH:17]2[CH2:21][CH2:20][CH2:19][N:18]2[CH3:22])[CH:8]=[CH:9][CH:10]=1.[ClH:27]>O1CCOCC1>[ClH:27].[OH:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][C:13]2[CH:26]=[CH:25][CH:24]=[CH:23][C:14]=2[O:15][CH2:16][CH:17]2[CH2:21][CH2:20][CH2:19][N:18]2[CH3:22])[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19423847HCID 19423847, compound

Product 1

HCID 19424037HCID 19424037, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

660 mg of 2-{2-[2-(3-methoxymethoxyphenyl)ethyl]phenoxymethyl}-1-methylpyrrolidine [prepared as described in step (a) above] were dissolved in 5 ml of a 4N solution of hydrogen chloride in dioxane, and the solution was allowed to stand at room temperature for 30 minutes. At the end of this time, the solvent was removed by distillation under reduced pressure, and the resulting solid residue was recrystallized from isopropyl alcohol, to give 529 mg (yield 82%) of the title compound as colorless needles, melting at 232°-233° C. (with decomposition).

Workup

  1. customAt the end of this time, the solvent was removed by distillation under reduced pressure
  2. customthe resulting solid residue was recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-c9c2e705a862484ca3a7bfb58a1a7e60
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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