反应详情

Following a procedure similar to that described in Example 35(a), 1.00 g of 2-[2-(2-methoxyphenyl)ethyl]phenol (prepared as described in Preparation 23), 1.47 g of potassium t-butoxide and 1.61 g of 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride were reacted in 10 ml of dimethylacetamide. The mixture was then worked up as described in Example 35(a), and the crude product thus obtained was purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 300 mg (yield 20%) of the title compound as an oil.

1. customthe crude product thus obtained
2. customwas purified by column chromatography through silica gel
3. additionby volume mixture of methylene chloride and methanol as the eluent