Hydrochloric Acid → HCID 19423872, compound

HRID 743306Notes

Reaction equation

HRID 743306 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:12][CH2:13][C:14]2[CH:28]=[CH:27][CH:26]=[CH:25][C:15]=2[O:16][CH2:17][CH2:18][CH:19]2[CH2:23][CH2:22][CH2:21][N:20]2[CH3:24])[CH:7]=[C:8]([O:10][CH3:11])[CH:9]=1>O1CCOCC1>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:12][CH2:13][C:14]2[CH:28]=[CH:27][CH:26]=[CH:25][C:15]=2[O:16][CH2:17][CH2:18][CH:19]2[CH2:23][CH2:22][CH2:21][N:20]2[CH3:24])[CH:7]=[C:8]([O:10][CH3:11])[CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 19423837HCID 19423837, compound

Product 1

HCID 19423872HCID 19423872, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using 0.9 ml of a 4N solution of hydrogen chloride in dioxane, 1.15 g of 2-(2-{2-[2-(3,5-dimethoxyphenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine [prepared as described in step (a) above] were converted to the hydrochloride, which was recrystallized from ethyl acetate to give 0.657 g (yield 52%) of the title compound as colorless crystals, melting at 99°-101° C.

Workup

  1. customwas recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-b7e664ff2bee4917baf09269e71e9215
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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