Hydrochloric Acid → HCID 10384875, compound

HRID 743365Notes

Reaction equation

HRID 743365 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[O:13][CH2:14][CH2:15][C@@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[CH3:21])[CH:6]=[CH:7][CH:8]=1.[ClH:26]>O1CCOCC1>[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[O:13][CH2:14][CH2:15][C@@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[CH3:21])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10384876HCID 10384876, compound

Product 1

HCID 10384875HCID 10384875, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.829 g of (S)-2-(2-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine was dissolved in 10 ml of dioxane, and 1.83 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution, which was then concentrated by distillation under reduced pressure. The resulting oil was dissolved in 15 ml of ethyl acetate, and the solution was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.741 g (yield 81%) of the title compound as colorless crystals, melting at 133°-135° C.

Workup

  1. concentrationwas then concentrated by distillation under reduced pressure
  2. dissolutionThe resulting oil was dissolved in 15 ml of ethyl acetate
  3. customto stand at room temperature
  4. customThe crystals which precipitated
  5. filtrationwere collected by filtration
  6. customdried in vacuo

Sources & evidence

ORD record
ord-8b2ae6e0ac0849c1932b18db575dcc8b
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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