Hydrochloric Acid → HCID 57497664, compound

HRID 743374Notes

Reaction equation

HRID 743374 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[O:13][CH2:14][C@H:15]2[CH2:20][CH2:19][CH2:18][N:17]([CH3:21])[CH2:16]2)[CH:6]=[CH:7][CH:8]=1.[ClH:26]>O1CCOCC1>[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[O:13][CH2:14][C@H:15]2[CH2:20][CH2:19][CH2:18][N:17]([CH3:21])[CH2:16]2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54492886HCID 54492886, compound

Product 1

HCID 57497664HCID 57497664, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1.80 g of (S)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxymethyl}-1-methylpiperidine [prepared as described in step (a) above], was dissolved in 10 ml of dioxane, and 1.5 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution, which was then concentrated by distillation under reduced pressure. The resulting oil was dissolved in 25 ml of ethyl acetate, and the solution was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 1.18 g (yield 59%) of the title compound as colorless crystals, melting at 206°-207° C.

Workup

  1. concentrationwas then concentrated by distillation under reduced pressure
  2. dissolutionThe resulting oil was dissolved in 25 ml of ethyl acetate
  3. customto stand at room temperature
  4. customThe crystals which precipitated
  5. filtrationwere collected by filtration
  6. customdried in vacuo

Sources & evidence

ORD record
ord-11d7e1cb219a4b2d95e0e57eae5f41b4
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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