反应详情

A solution of 3.00 g of 2-naphthaldehyde and 6.69 g of ethoxycarbonylmethylenetriphenylphosphorane in 100 ml of acetonitrile was heated under reflux for 1 hour, after which the reaction mixture was concentrated by evaporation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using 4:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 4.32 g (yield 99%) of ethyl 3-(2-naphthyl)-2-propenoate as a colorless solid.

1. temperatureunder reflux for 1 hour
2. concentrationafter which the reaction mixture was concentrated by evaporation under reduced pressure
3. customThe resulting residue was purified by column chromatography through silica gel
4. additionby volume mixture of hexane and ethyl acetate as the eluent