1-(2-Benzyloxyphenyl)-4-(2-chlorophenyl)butane → 2-[4-(2-Chlorophenyl)butyl]phenol

Participants

Reaction Steps

Finally, following a procedure similar to that described in the final part of Preparation 15, the whole of this 1-(2-benzyloxyphenyl)-4-(2-chlorophenyl)butane was dissolved in 18 ml of methylene chloride and debenzylated by means of 8.15 ml of a 1M solution of boron tribromide in methylene chloride. The crude product thus obtained was purified by column chromatography through silica gel, using a 4:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2.0 g (yield 94%) of the title compound as a colorless solid.

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