反应详情

3-Ethoxycarbonyl-7,8-difluoro-4-oxo-1-tert-butyl-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions described in Example 10, but starting with 4 g of ethyl 2-(2-chloro-6,7-difluoro-3-quinolylcarbonyl)-3(dimethylamino)acrylate and 0.87 g of tert-butylamine. 2.7 g of 3-ethoxycarbonyl-7,8-difluoro-4-oxo-1-tert-butyl-1,4dihydrobenzo[b][1,8]naphthyridine are obtained in the form of a yellow solid, melting point 206° C., which is used without further purification for the subsequent steps.

1. custom3-Ethoxycarbonyl-7,8-difluoro-4-oxo-1-tert-butyl-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions