Trifluoroacetic acid → HCID 22865519, compound

HRID 743671Notes

Reaction equation

HRID 743671 reaction equation
C([O:5][C:6](=[O:50])[C@H:7]([CH2:23][C:24](=[O:49])[NH:25][C@@H:26]1[O:43][C@H:42]([CH2:44][O:45][C:46](=[O:48])[CH3:47])[C@@H:37]([O:38][C:39](=[O:41])[CH3:40])[C@H:32]([O:33][C:34](=[O:36])[CH3:35])[C@H:27]1[O:28][C:29](=[O:31])[CH3:30])[NH:8][S:9]([C:12]1[C:17]([CH3:18])=[CH:16][C:15]([O:19][CH3:20])=[C:14]([CH3:21])[C:13]=1[CH3:22])(=[O:11])=[O:10])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl.CO>[CH3:20][O:19][C:15]1[CH:16]=[C:17]([CH3:18])[C:12]([S:9]([NH:8][C@H:7]([C:6]([OH:50])=[O:5])[CH2:23][C:24](=[O:49])[NH:25][C@@H:26]2[O:43][C@H:42]([CH2:44][O:45][C:46](=[O:48])[CH3:47])[C@@H:37]([O:38][C:39](=[O:41])[CH3:40])[C@H:32]([O:33][C:34](=[O:36])[CH3:35])[C@H:27]2[O:28][C:29](=[O:31])[CH3:30])(=[O:11])=[O:10])=[C:13]([CH3:22])[C:14]=1[CH3:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22865520HCID 22865520, compound

Product 1

HCID 22865519HCID 22865519, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Compound 15 (1.5 g) was hydrolyzed with trifluoroacetic acid and worked up as described for compound 19.Yield: 1.0 g. TLC analysis: Rf=0.07 (chloroform/methanol/glacial acetic acid 5:1:0.1 )

Sources & evidence

ORD record
ord-e700fc4ffffd4f4792a22cd6a53d7dd6
Source dataset
uspto-grants-1996_09
Patent number
US05556941

Reaction notes

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