Phosphorus trichloride → HCID 19421143, compound

Participants

Reaction Steps

Scheme III shows the reaction of 2,5-dimethylbenzoic acid chloride with benzoic hydrazide in the presence of triethylamine to give 1-(1,4-dimethylbenzoyl)-2-benzoylhydrazine. The resultant 1-(1,4-dimethylbenzoyl)-2-benzoylhydrazine is then allowed to cyclize in the presence of phosphorus chloride to give 2-(1,4-dimethylphenyl)-5-phenyl-1,3,4-oxadiazole, that then undergoes direct bromination or oxidation, as described above, to produce bis(bromomethyl) and bis(chloromethyl) monomers.

Provenance & Evidence