反应详情

3,5-Dichloropyridazine, which is known in the art, (2.0 g, 0.0135 moles) and sodium thiomethoxide (1.14 g, 0.0162 moles) were stirred in THF (50 mL) at RT under N2 for 2 h. The mixture was then poured into water and extracted 2×100 mL with ethyl acetate. The organic layer was dried (MgSO4), filtered and evaporated in-vacuo to give a crude solid which was recrystallized from cyclohexane/ethyl acetate to give 3-chloro-5(methylthio)pyridazine (1.64 g, 76% yield) as a brown solid, mp=98° C.-100° C.

1. extractionextracted 2×100 mL with ethyl acetate
2. dry with materialThe organic layer was dried (MgSO4)
3. filtrationfiltered
4. customevaporated in-vacuo
5. customto give a crude solid which
6. customwas recrystallized from cyclohexane/ethyl acetate