Trifluoroacetic acid → HCID 54248163, compound

HRID 743978Notes

Reaction equation

HRID 743978 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19]C(=O)OC(C)(C)C)[CH3:12])[N:4]=1.FC(F)(F)C(O)=O>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH2:19])[CH3:12])[N:4]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54081528HCID 54081528, compound

Product 1

HCID 54248163HCID 54248163, compound

Procedure

The product of stage (b) above (5.0 g) was added to trifluoroacetic acid (25 ml) and the resulting solution was stirred at room temperature for 3 hours. The solution was evaporated and the residue was triturated with diisopropyl ether and cooled in a solid carbon dioxide-acetone bath. The solid was filtered and washed with diisopropyl ether to give 3.5 g of the desired product, mp 136°-139° C.

Workup

  1. customThe solution was evaporated
  2. customthe residue was triturated with diisopropyl ether
  3. temperaturecooled in a solid carbon dioxide-acetone bath
  4. filtrationThe solid was filtered
  5. washwashed with diisopropyl ether

Sources & evidence

ORD record
ord-677fd29b013a4a68a1840414cfb864b0
Source dataset
uspto-grants-1996_09
Patent number
US05559081

Reaction notes

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