HCID 53774573, compound → HCID 53805954, compound

HRID 743991Notes

Reaction equation

HRID 743991 reaction equation
[CH2:1]([C:5]1[N:6]([CH3:28])[C:7]([C:10](=[O:27])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=2[O:19]CC2C=CC=CC=2)=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]>CCOC(C)=O.[Pd]>[CH2:1]([C:5]1[N:6]([CH3:28])[C:7]([C:10](=[O:27])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=2[OH:19])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 53774573HCID 53774573, compound

Product 1

HCID 53805954HCID 53805954, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2-n-Butyl-1-methyl-5-(2-benzyloxy-4-methoxybenzoyl)-1H-imidazole (1.29 g, 3.41 mmol) dissolved in EtOAc was treated with 10% Pd/C under H2 (1 atm) for 10 h at ambient temperature. The catalyst was removed by filtration and the solvent removed under reduced pressure to afford the title compound as a bright yellow oil which solidified on standing (888 mg, 91%)

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-bc25567f139c4f00a0a35349af30cece
Source dataset
uspto-grants-1996_09
Patent number
US05559105

Reaction notes

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