HCID 19421391, compound → HCID 19421374, compound

HRID 743996Notes

Reaction equation

HRID 743996 reaction equation
C([O:8][C:9]1[CH:34]=[C:33]([O:35][CH3:36])[CH:32]=[CH:31][C:10]=1[C:11]([C:13]1[N:17]([O:18][CH2:19][O:20][CH:21]([Si:23]([CH3:26])([CH3:25])[CH3:24])[CH3:22])[C:16]([CH2:27][CH2:28][CH2:29][CH3:30])=[N:15][CH:14]=1)=[O:12])C1C=CC=CC=1>CCOC(C)=O.[Pd]>[CH2:27]([C:16]1[N:17]([O:18][CH2:19][O:20][CH:21]([Si:23]([CH3:24])([CH3:26])[CH3:25])[CH3:22])[C:13]([C:11](=[O:12])[C:10]2[CH:31]=[CH:32][C:33]([O:35][CH3:36])=[CH:34][C:9]=2[OH:8])=[CH:14][N:15]=1)[CH2:28][CH2:29][CH3:30]

Participants

4

Reactant 1

HCID 19421391HCID 19421391, compound

Product 1

HCID 19421374HCID 19421374, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 5-(2-Benzyloxy-4-methoxybenzoyl)-2-n-butyl-1-trimethylsilylethyloxymethoxy-1H-imidazole (549 mg, 1.1 mmol) in EtOAc (15 ml) was stirred with 10% Pd/C (87 mg) under H2 (1 atm) for 18 h. Filtration and evaporation afforded the title compound as a yellow oil (407 mg, 91% ).

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-9b1390ddb3c34f199f3f072978500a0e
Source dataset
uspto-grants-1996_09
Patent number
US05559105

Reaction notes

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