反应详情

To a solution of 10.0 g (~36.9 mmol) of 7-cyano-1-hydroxy-6-trifluoromethylquinoxaline-2,3(1H,4H)-dione in a mixture of 700 ml of ethanol and 175 ml of 1M potassium dihydrogen phosphate buffer pH 7.4 was added 14 g (~81 mmol) of benzylbromide. Stirring was continued for 2 h at 25° C. The precipitate was filtered off and washed with ice-cold ethanol to give the title compound (9.9 g; 75%).

1. filtrationThe precipitate was filtered off
2. washwashed with ice-cold ethanol