Hydrochloric Acid → HCID 19421448, compound

HRID 744008Notes

Reaction equation

HRID 744008 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[C:13]([F:16])([F:15])[F:14])[N:9]1[C:17]([CH2:20][CH2:21][C:22]([O:24]CC)=[O:23])=[N:18][N:19]=[C:8]1[C:7](=[O:27])[NH:6]2)#[N:2].[OH-].[Na+].Cl>>[C:22]([CH2:21][CH2:20][C:17]1[N:9]2[C:10]3[C:5]([NH:6][C:7](=[O:27])[C:8]2=[N:19][N:18]=1)=[CH:4][C:3]([C:1]#[N:2])=[C:12]([C:13]([F:15])([F:16])[F:14])[CH:11]=3)([OH:24])=[O:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19421439HCID 19421439, compound

Product 1

HCID 19421448HCID 19421448, compoundYield 63.5%

Conditions

Temperature
25 °C

Procedure

A mixture of 0.5 g (~1.3 mmol) of 7-cyano-1-(2-ethoxycarbonylethyl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one and 25 ml of 1N sodium hydroxide was stirred at 25° C. for 2 h. The solution was cooled in an ice bath and acidified with 4N hydrochloric acid to pH=2. The precipitate was filtered off to give 0.29 g (~63%) of the title compound.

Workup

  1. temperatureThe solution was cooled in an ice bath
  2. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-401f92af89a24011a1071037ce284964
Source dataset
uspto-grants-1996_09
Patent number
US05559106

Reaction notes

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