Hydrochloric Acid → HCID 19421408, compound

HRID 744009Notes

Reaction equation

HRID 744009 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][C:8]1[N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[C:11]2=[N:10][N:9]=1)=[CH:17][C:16]([C:22]([F:25])([F:24])[F:23])=[CH:15][CH:14]=3)=[O:5])C.Cl>[OH-].[Na+]>[C:4]([CH2:6][CH2:7][C:8]1[N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[C:11]2=[N:10][N:9]=1)=[CH:17][C:16]([C:22]([F:24])([F:25])[F:23])=[CH:15][CH:14]=3)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19421416HCID 19421416, compound

Product 1

HCID 19421408HCID 19421408, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A suspension of 1-(2-ethoxycarbonylethyl)-7-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one (177 mg, 0.5 mmol) in 6 ml of 1N sodium hydroxide was stirred at room temperature for 150 min. The solution was cooled in an ice bath and acidified with 4M hydrochloric acid to pH 1. The precipitate was isolated by filtration, washed with water, ethanol and ether to give 131 mg (80%) of the title compound. M.p. 333° C. (DSC).

Workup

  1. temperatureThe solution was cooled in an ice bath
  2. customThe precipitate was isolated by filtration
  3. washwashed with water, ethanol and ether

Sources & evidence

ORD record
ord-8ffc28cb020341acbe804c7f19aa7d28
Source dataset
uspto-grants-1996_09
Patent number
US05559106

Reaction notes

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