Benzyl Bromide → HCID 54449768, compound

HRID 744010Notes

Reaction equation

HRID 744010 reaction equation
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:9][N:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20]([F:23])([F:22])[F:21])[CH:18]=2)[NH:13][C:12](=[O:24])[C:11]1=[O:25]>C(O)C.P([O-])(O)(O)=O.[K+]>[CH2:1]([O:9][N:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20]([F:23])([F:21])[F:22])[CH:18]=2)[NH:13][C:12](=[O:24])[C:11]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 7498Benzyl BromideHCID 19421436HCID 19421436, compound

Product 1

HCID 54449768HCID 54449768, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 516951Monobasic potassium phosphateSolvent

Procedure

Benzyl bromide (72 ml, 0.60 mol) was added to a suspension of 1-hydroxy-7-trifluoromethylquinoxaline-2,3(1H,4H)-dione (49.2 g, 0.20 mol) in 2.5 l of ethanol and 800 ml of 1M potassium dihydrogen phosphate buffer (pH 7.4). The mixture was stirred at room temperature overnight, and filtered. The precipitate was washed with water and dried to give 59.5 g (89%) of the title compound. M.p.>220° C. decomp.

Workup

  1. filtrationfiltered
  2. washThe precipitate was washed with water
  3. customdried

Sources & evidence

ORD record
ord-6418dfcf6bda426c889f104ef80ee2d7
Source dataset
uspto-grants-1996_09
Patent number
US05559106

Reaction notes

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