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温度

0 °C

A solution of 20% phosgene in toluene (120 ml, 0.23 mol) was added to a solution of 1-benzyl-7-trifluoromethylquinoxaline-2,3(1H,4H)-dione (27 g, 80 mmol) in 300 ml of dry N,N-dimethylformamide with stirring at 0° C. The mixture was stirred at room temperature overnight and evaporated to dryness. The residue was triturated with ice/water, filtered and dried in vacuo over phosphorus pentoxide to give 27.4 g (96%) of the title compound. M.p. 148°-150° C.

1. stirringThe mixture was stirred at room temperature overnight
2. customevaporated to dryness
3. customThe residue was triturated with ice/water
4. filtrationfiltered
5. dry with materialdried in vacuo over phosphorus pentoxide