反应详情

A solution of 3-(2-diethoxyphosphorylacetyl)hydrazino-1-(2,4-dimethoxybenzyl)benzo[f]quinoxalin-2(1H)-one (1.1 g crude product) and glacial acetic acid (40 ml) was heated under reflux for 12 h. The mixture was evaporated to dryness. The residue was recrystallized from isopropanol to give 400 mg of the title compound m.p. 195°-197° C. 1H-NMR (DMSO-d6): δ 1.18 (t, 6H), 4.08 (quint, 4H), 4.35 (d, 2H), 7.68 (m, 2H), 7.90 (d, 1H), 8.08 (m, 1H), 8.35 (d, 1H), 8.82 (m, 1H), 12.25 (s, 1H).

1. temperatureunder reflux for 12 h
2. customThe mixture was evaporated to dryness
3. customThe residue was recrystallized from isopropanol